Article
Inferring relative proportions of DNA variants from sequencing electropherograms.
Bioinformatics (Oxford, England) - 15 Dec 2009
Carr I M, Robinson J I, Dimitriou R, Markham A F, Morgan A W, Bonthron D T
Abstract excerpt
MOTIVATION: Determination of the relative copy number of single-nucleotide sequence variants (SNVs) within a DNA sample is a frequent experimental goal. Various methods can be applied to this problem, although hybridization-based approaches tend to suffer from high-setup cost and poor adaptability, while others (such as pyrosequencing) may not be accessible to all laboratories. The potential to extract relative...
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