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Article

An enhanced elastic network model to represent the motions of domain-swapped proteins.

Proteins - 1 Apr 2006

Song Guang, Jernigan Robert L

Abstract excerpt

Domain swapping is a process where two (or more) protein molecules form a dimer (or higher oligomer) by exchanging an identical domain. In this article, based on the observation that domains are rigid and hinge loops are highly flexible, we propose a new Elastic Network Model, domain-ENM, for domain-swapped proteins. In this model, the rigidity of domains is taken into account by using a larger spring constant...

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PMID: 16447281
DOI: 10.1002/prot.20836

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