Article
Using Accelerated Molecular Dynamics Simulation to elucidate the effects of the T198F mutation on the molecular flexibility of the West Nile virus envelope protein.
Scientific reports - 15 Jun 2020
Valente Renan Patrick da Penha, Souza Rafael Conceição de, de Medeiros Muniz Gabriela, Ferreira João Elias Vidueira, de Miranda Ricardo Morais, E Lima Anderson Henrique Lima, Vianez Junior João Lídio da Silva Gonçalves
Abstract excerpt
The envelope (E) protein is an important target for antibodies in flavivirus. Literature reports that the mutation T198F, located at the domain I-II hinge of the E protein, regulates viral breathing and increases the accessibility of a distal cryptic epitope located on the fusion loop, having a direct impact in the neutralization of West Nile virus (WNV). Our study aimed to describe, using accelerated molecular...
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