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RNAi‐mediated MEK1 knock‐down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth <i>in vitro</i> and <i>in vivo</i>

8 Oct 2009

Abstract excerpt

The mitogen-activated protein kinases MEK/ERK pathway regulates fundamental processes in malignant cells and represents an attractive target in the development of new cancer treatments especially for human hepatocarcinoma highly resistant to chemotherapy. Although gene extinction experiments have suggested distinct roles for these proteins, the MEK/ERK cascade remains widely considered as exhibiting an overlap of...

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PMID: 19816936
DOI: 10.1002/ijc.24950

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