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The tyrosine kinase Yes1 is a druggable host factor of HEV

17 Oct 2024

Abstract excerpt

BACKGROUND: HEV is a positive-sense, single-stranded RNA virus of the Hepeviridae family. Although HEV accounts for more than 3 million symptomatic cases of viral hepatitis per year, specific anti-HEV therapy and knowledge about HEV pathogenesis are scarce. METHODS: To gain a deeper understanding of the HEV infectious cycle and guide the development of novel antiviral strategies, we here used an RNAi mini screen...

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PMID: 39560373
DOI: 10.1097/hc9.0000000000000553

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