Article
Progenitor cells from the explanted heart generate immunocompatible myocardium within the transplanted donor heart.
Circulation research - 20 Nov 2009
D'Alessandro David A, Kajstura Jan, Hosoda Toru, Gatti Alessandro, Bello Ricardo, Mosna Federico, Bardelli Silvana, Zheng Hanqiao, D'Amario Domenico, Padin-Iruegas M Elena, Carvalho Adriana Bastos, Rota Marcello, Zembala Michael O, Stern David, Rimoldi Ornella, Urbanek Konrad, Michler Robert E, Leri Annarosa, Anversa Piero
Abstract excerpt
RATIONALE: Chronic rejection, accelerated coronary atherosclerosis, myocardial infarction, and ischemic heart failure determine the unfavorable evolution of the transplanted heart in humans. OBJECTIVE: Here we tested whether the pathological manifestations of the transplanted heart can be corrected partly by a strategy that implements the use of cardiac progenitor cells from the recipient to repopulate the donor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
