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Article

Macrocyclic diterpenes resensitizing multidrug resistant phenotypes.

Bioorganic & medicinal chemistry - 15 Jul 2014

Reis Mariana A, Paterna Angela, Ferreira Ricardo J, Lage Hermann, Ferreira Maria-José U

Abstract excerpt

Herein, collateral sensitivity effect was exploited as a strategy to select effective compounds to overcome multidrug resistance in cancer. Thus, eleven macrocyclic diterpenes, namely jolkinol D (1), isolated from Euphorbia piscatoria, and its derivatives (2-11) were evaluated for their activity on three different Human cancer entities: gastric (EPG85-257), pancreatic (EPP85-181) and colon (HT-29) each with a...

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PMID: 24864039
DOI: 10.1016/j.bmc.2014.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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