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Article

PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally.

Antimicrobial agents and chemotherapy - 1 Dec 2016

Graci Jason D, Jung Stephen P, Pichardo John, Lahser Frederick, Tong Xiao, Gu Zhengxian, Colacino Joseph M

Abstract excerpt

PTC725 is a small molecule NS4B-targeting inhibitor of hepatitis C virus (HCV) genotype (gt) 1 RNA replication that lacks activity against HCV gt2. We analyzed the Los Alamos HCV sequence database to predict susceptible/resistant HCV gt's according to the prevalence of known resistance-conferring amino acids in the NS4B protein. Our analysis predicted that HCV gt3 would be highly susceptible to the activity of...

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Identifiers

PMID: 27620477
DOI: 10.1128/AAC.01272-16
PMCID: PMC5118984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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