Article
Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women.
The Journal of antimicrobial chemotherapy - 1 Dec 2009
Chantarangsu Soranun, Cressey Tim R, Mahasirimongkol Surakameth, Capparelli Edmund, Tawon Yardpiroon, Ngo-Giang-Huong Nicole, Jourdain Gonzague, Lallemant Marc, Chantratita Wasun
Abstract excerpt
OBJECTIVES: To investigate the association of single nucleotide polymorphisms (SNPs) with nevirapine concentrations following intra-partum single-dose nevirapine. METHODS: Plasma and DNA samples were obtained from 330 HIV-infected Thai women who received intra-partum single-dose nevirapine in the PHPT-2 clinical trial to prevent perinatal HIV transmission. Nine SNPs within CYP2B6, CYP3A4 and ABCB1 were genotyped...
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