A comparison of 3 regimens to prevent nevirapine resistance mutations in HIV-infected pregnant women receiving a single intrapartum dose of nevirapine.

doi:10.1093/cid/cir798

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Article

A comparison of 3 regimens to prevent nevirapine resistance mutations in HIV-infected pregnant women receiving a single intrapartum dose of nevirapine.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2012

Van Dyke Russell B, Ngo-Giang-Huong Nicole, Shapiro David E, Frenkel Lisa, Britto Paula, Roongpisuthipong Anuvat, Beck Ingrid A, Yuthavisuthi Praparb, Prommas Sinart, Puthanakit Thanyawee, Achalapong Jullapong, Chotivanich Nantasak, Rasri Wirawan, Cressey Tim R, Maupin Robert, Mirochnick Mark, Jourdain Gonzague

Abstract excerpt

BACKGROUND: Intrapartum single-dose (SD) nevirapine (NVP) reduces perinatal transmission of human immunodeficiency virus (HIV) infection but selects for NVP-resistant virus, which compromises subsequent NVP-based therapy. A 1-week "tail" of lamivudine and zidovudine after SD-NVP decreases the risk of resistance. We hypothesized that increasing the duration or potency of the tail would further reduce this risk to...

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PMID: 22144539
DOI: 10.1093/cid/cir798
PMCID: PMC3245730

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