Article
Activation of tat-defective human immunodeficiency virus by ultraviolet light.
The New biologist - 1 May 1990
Sadaie M R, Tschachler E, Valerie K, Rosenberg M, Felber B K, Pavlakis G N, Klotman M E, Wong-Staal F
Abstract excerpt
Ultraviolet light (UV) is known to cause activation of gene expression from the human immunodeficiency virus type 1 (HIV-1) promoter. To address the question of whether tat-defective HIV-1 provirus could be rescued by UV irradiation we examined its effect on HeLa cells containing integrated provi...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cloning, Molecular
- DNA, Viral
- Fluorescent Antibody Technique
- Gene Products, tat
- HIV-1
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Proviruses
- Tumor Cells, Cultured
- Virus Activation
- tat Gene Products, Human Immunodeficiency Virus