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Activation of tat-defective human immunodeficiency virus by ultraviolet light.

The New biologist - 1 May 1990

Sadaie M R, Tschachler E, Valerie K, Rosenberg M, Felber B K, Pavlakis G N, Klotman M E, Wong-Staal F

Abstract excerpt

Ultraviolet light (UV) is known to cause activation of gene expression from the human immunodeficiency virus type 1 (HIV-1) promoter. To address the question of whether tat-defective HIV-1 provirus could be rescued by UV irradiation we examined its effect on HeLa cells containing integrated proviruses with tat mutations. Exposure of these cells to an optimal dose of UV resulted in the production of infectious...

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PMID: 1981148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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