Article
HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes.
Immunological investigations - 1 Jan 2009
Zepeda-Gomez Sergio, Montaño-Loza Aldo, Zapata-Colindres Juan Carlos, Paz Francisco, Olivera-Martinez Marco, López-Reyes Alberto, Granados Julio, Vargas-Alarcón Gilberto
Abstract excerpt
Autoimmune liver diseases are sometimes difficult to differentiate from hepatic overlap syndromes (OS). The objective of this study was to use polymorphic genetic markers to better distinguish clinical heterogeneity in autoimmune liver disease. Since autoimmunity is the result of autoantibody production we studied HLA-DR alleles in 20 patients with autoimmune hepatitis (AIH), 16 with primary biliary cirrhosis...
Topics
- Antibodies, Antinuclear
- Autoimmune Diseases
- Biomarkers
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DR Antigens
- Humans
- Immunoglobulin G
- Liver Diseases
- Liver Function Tests