Article
The role of direct oligonucleotide repeats in gonococcal pilin gene variation.
Molecular microbiology - 1 Aug 1990
Hill S A, Morrison S G, Swanson J
Abstract excerpt
Previous studies indicate that gonococcal pilin phase and antigenic variation occur by intragenomic pilin gene recombination, the outcome of which resembles that of gene conversion. During such transitions, the expressed complete pilin gene (pilE) acquires a novel sequence corresponding to that of a silent pilin gene (pilS). In the present study, we find that internal deletions of pilE can produce pilus-/pilus+...
Topics
- Bacterial Outer Membrane Proteins
- Base Sequence
- Fimbriae Proteins
- Fimbriae, Bacterial
- Genes, Bacterial
- Genetic Variation
- Molecular Sequence Data
- Neisseria gonorrhoeae
- Oligodeoxyribonucleotides
- Repetitive Sequences, Nucleic Acid