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Article

ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis

5 Oct 2009

Abstract excerpt

The small GTPase Ras is mutated to remain in the active oncogenic state in one-third of human cancers, thereby promoting tumorigenesis. It has recently come to light that one consequence of oncogenic Ras signaling is secretion of cytokines vascular endothelial growth factor (VEGF), interleukin 6 (IL6), hCXCL1 (Gro-alpha) and hCXCL8 (IL8). As the latter two belong to the ELR+ Cys-X-Cys (CXC) chemokine family, we...

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PMID: 19805574
DOI: 10.1093/carcin/bgp198

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