Article
The chemokine system and cancer.
The Journal of pathology - 1 Jan 2012
Balkwill Frances R
Abstract excerpt
Chemokines (chemo-attractant cytokines) are a group of small proteins that act together with their cell surface receptors, in development, normal physiology and immune responses, to direct cells to specific locations throughout the body. Cancer cells acquire the ability to subvert the chemokine system, such that these molecules and their receptors become important regulators of cell movement into and out of the...
Topics
- Cell Transformation, Neoplastic
- Chemokines
- Embryonic Development
- Humans
- Leukocytes
- Mutation
- Neoplasms
- Oncogenes
- Receptors, Chemokine
- Signal Transduction
- Tumor Microenvironment