Article
Function and molecular mechanism of acetylation in autophagy regulation.
Science (New York, N.Y.) - 27 Apr 2012
Yi Cong, Ma Meisheng, Ran Leili, Zheng Jingxiang, Tong Jingjing, Zhu Jing, Ma Chengying, Sun Yufen, Zhang Shaojin, Feng Wenzhi, Zhu Liyuan, Le Yan, Gong Xingqi, Yan Xianghua, Hong Bing, Jiang Fen-Jun, Xie Zhiping, Miao Di, Deng Haiteng, Yu Li
Abstract excerpt
Protein acetylation emerged as a key regulatory mechanism for many cellular processes. We used genetic analysis of Saccharomyces cerevisiae to identify Esa1 as a histone acetyltransferase required for autophagy. We further identified the autophagy signaling component Atg3 as a substrate for Esa1. Specifically, acetylation of K19 and K48 of Atg3 regulated autophagy by controlling Atg3 and Atg8 interaction and...
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