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Article

Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP.

Cell death and differentiation - 1 Aug 2007

Mimura N, Hamada H, Kashio M, Jin H, Toyama Y, Kimura K, Iida M, Goto S, Saisho H, Toshimori K, Koseki H, Aoe T

Abstract excerpt

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR), which alleviates protein overload in the secretory pathway. Although the UPR is activated under diverse pathological conditions, its physiological role during development and in adult...

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Share to Endoplasmic Reticulum Chaperone BiP
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Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pulmonary Alveoli

Share to Pulmonary Surfactant-Associated Protein A

Share to Pulmonary Surfactant-Associated Protein C

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Source

Identifiers

PMID: 17464327
DOI: 10.1038/sj.cdd.4402151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17464327-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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