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Article

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009

Kang Min-Ji, Ryoo Hyung Don

Abstract excerpt

Mutations in the rhodopsin gene that disrupt the encoded protein's folding properties are a major cause of autosomal dominant retinitis pigmentosa (ADRP). This disease is faithfully modeled in Drosophila where similar mutations in the ninaE gene, encoding rhodopsin-1 (Rh-1), cause ER stress and dominantly trigger age-related retinal degeneration. In addition, mutant flies bearing certain ninaE alleles have...

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Identifiers

PMID: 19805114
DOI: 10.1073/pnas.0905566106
PMCID: PMC2749843

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Source receipt: pubmed, retrieved 7 Sept 2026.

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