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Article

AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity.

Human molecular genetics - 28 May 2020

Aguilà Monica, Bellingham James, Athanasiou Dimitra, Bevilacqua Dalila, Duran Yanai, Maswood Ryea, Parfitt David A, Iwawaki Takao, Spyrou Giannis, Smith Alexander J, Ali Robin R, Cheetham Michael E

Abstract excerpt

Rhodopsin misfolding caused by the P23H mutation is a major cause of autosomal dominant retinitis pigmentosa (adRP). To date, there are no effective treatments for adRP. The BiP co-chaperone and reductase ERdj5 (DNAJC10) is part of the endoplasmic reticulum (ER) quality control machinery, and previous studies have shown that overexpression of ERdj5 in vitro enhanced the degradation of P23H rhodopsin, whereas...

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Identifiers

PMID: 32196553
DOI: 10.1093/hmg/ddaa049
PMCID: PMC7254845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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