Article
A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors.
BMC medical genomics - 30 Jun 2010
Loboda Andrey, Nebozhyn Michael, Klinghoffer Rich, Frazier Jason, Chastain Michael, Arthur William, Roberts Brian, Zhang Theresa, Chenard Melissa, Haines Brian, Andersen Jannik, Nagashima Kumiko, Paweletz Cloud, Lynch Bethany, Feldman Igor, Dai Hongyue, Huang Pearl, Watters James
Abstract excerpt
BACKGROUND: Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signature that is predictive of RAS pathway dependence. METHODS: We used the coherent expression of RAS pathway-related...
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