Article
Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family.
DNA sequence : the journal of DNA sequencing and mapping - 1 Jan 1991
Endicott J A, Sarangi F, Ling V
Abstract excerpt
The only function of the transport protein P-glycoprotein (Pgp) that has been identified to date in mammals is its ability to mediate multidrug resistance (MDR) in tumour cell lines. Rodents have three P-glycoprotein (pgp) genes (termed pgp or mdr 1, 2 and 3), and humans have two (mdr1 and mdr3/mdr2). Pgp isoforms differ in their drug transport capabilities: Pgp1 and Pgp2 can mediate MDR, while Pgp3 apparently...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Cricetinae
- Cricetulus
- DNA
- Genetic Variation
- Humans
- Membrane Glycoproteins