Article
Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.
The Journal of biological chemistry - 13 Jul 2001
Garrigue-Antar L, Barker C, Kadler K E
Abstract excerpt
Bone morphogenetic protein (BMP)-1, which belongs to the tolloid subgroup of astacin-like zinc metalloproteinases, cleaves the C-propeptides of procollagen at the physiologic site and is, therefore, a procollagen C-proteinase (PCP). Cleavage occurs between a specific alanine or glycine residue (depending on the procollagen chain) and an invariant aspartic acid residue in each of the three chains of procollagen....
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