Article
The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains.
Biological chemistry - 1 May 2007
Wermter Carsten, Höwel Markus, Hintze Vera, Bombosch Bettina, Aufenvenne Karin, Yiallouros Irene, Stöcker Walter
Abstract excerpt
Procollagen C-proteinase (PCP) removes the C-terminal pro-peptides of procollagens and also processes other matrix proteins. The major splice form of the PCP is termed BMP1 (bone morphogenetic protein 1). Active BMP1 is composed of an astacin-like protease domain, three CUB (complement, sea urchin Uegf, BMP1) domains and one EGF-like domain. Here we compare the recombinant human full-length BMP1 with its isolated...
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