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Identification of Two Aflatrem Biosynthesis Gene Loci in<i>Aspergillus flavus</i>and Metabolic Engineering of<i>Penicillium paxilli</i>To Elucidate Their Function

3 Oct 2009

Abstract excerpt

Aflatrem is a potent tremorgenic toxin produced by the soil fungus Aspergillus flavus, and a member of a structurally diverse group of fungal secondary metabolites known as indole-diterpenes. Gene clusters for indole-diterpene biosynthesis have recently been described in several species of filamentous fungi. A search of Aspergillus complete genome sequence data identified putative aflatrem gene clusters in the...

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PMID: 19801473
DOI: 10.1128/aem.02146-08

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