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Article

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.

Archives of biochemistry and biophysics - 1 Dec 2009

Galaleldeen Ahmad, Strange Richard W, Whitson Lisa J, Antonyuk Svetlana V, Narayana Narendra, Taylor Alexander B, Schuermann Jonathan P, Holloway Stephen P, Hasnain S Samar, Hart P John

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the destruction of motor neurons in the spinal cord and brain. A subset of ALS cases are linked to dominant mutations in copper-zinc superoxide dismutase (SOD1). The pathogenic SOD1 variants A4V and G93A have been the foci of multiple studies aimed at understanding the molecular basis for SOD1-linked ALS. The...

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Identifiers

PMID: 19800308
DOI: 10.1016/j.abb.2009.09.020
PMCID: PMC2787720

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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