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Article

Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.

Journal of molecular biology - 22 Nov 2002

Cardoso Rosa M F, Thayer Maria M, DiDonato Michael, Lo Terence P, Bruns Cami K, Getzoff Elizabeth D, Tainer John A

Abstract excerpt

Mutations in human superoxide dismutase (HSOD) have been linked to the familial form of amyotrophic lateral sclerosis (FALS). Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) is one of the most common neurodegenerative disorders in humans. In ALS patients, selective killing of motor neurons leads to progressive paralysis and death within one to five years of onset. The most frequent FALS mutation in...

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PMID: 12441104
DOI: 10.1016/s0022-2836(02)01090-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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