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Article

Effect of a specific cyclooxygenase-gene polymorphism (A-842G/C50T) on the occurrence of peptic ulcer hemorrhage.

Digestive diseases and sciences - 1 Dec 2006

van Oijen Martijn G H, Laheij Robert J F, Koetsier Marjolein, de Kleine Evelien, Te Morsche René H M, van Kerkhoven Lieke A S, Jansen Jan B M J, Drenth Joost P H

Abstract excerpt

Cyclooxygenases (COX) catalyze the conversion of arachidonic acid to prostaglandins (PGs). COX-inhibiting drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), increase the risk for peptic ulcer disease. As a corollary, COX gene polymorphisms could be important in the pathogenesis of peptic ulcer disease because these affect prostaglandin formation and impair its protective effect at the level of the...

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PMID: 17078001
DOI: 10.1007/s10620-006-9475-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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