Article
Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study.
Annals of medicine - 1 Dec 2022
Mallah Narmeen, Zapata-Cachafeiro Maruxa, Aguirre Carmelo, Ibarra-García Eguzkiñe, Palacios-Zabalza Itziar, Macías-García Fernando, Piñeiro-Lamas María, Ibáñez Luisa, Vidal Xavier, Vendrell Lourdes, Martin-Arias Luis, Sáinz-Gil María, Velasco-González Verónica, Bacariza-Cortiñas Manuel, Salgado Angel, Estany-Gestal Ana, Figueiras Adolfo
Abstract excerpt
BACKGROUND: Interindividual genetic variations contribute to differences in patients' response to drugs as well as to the development of certain disorders. Patients who use non-steroidal anti-inflammatory drugs (NSAIDs) may develop serious gastrointestinal disorders, mainly upper gastrointestinal haemorrhage (UGIH). Studies about the interaction between NSAIDs and genetic variations on the risk of UGIH are...
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