A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users.

doi:10.1038/s41598-021-99402-w

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Article

A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users.

Scientific reports - 7 Oct 2021

Mallah Narmeen, Zapata-Cachafeiro Maruxa, Aguirre Carmelo, Ibarra-García Eguzkiñe, Palacios-Zabalza Itziar, Macías García Fernando, Iglesias García Julio, Piñeiro-Lamas María, Ibáñez Luisa, Vidal Xavier, Vendrell Lourdes, Martin-Arias Luis, Gil María Sáinz, Velasco-González Verónica, Salgado-Barreira Ángel, Figueiras Adolfo

Abstract excerpt

Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable number tandem repeat (VNTR) polymorphism with upper gastrointestinal hemorrhage (UGIH) in NSAID exposed and unexposed populations and assessed any interaction between this polymorphism and NSAIDs....

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Identifiers

PMID: 34620931
DOI: 10.1038/s41598-021-99402-w
PMCID: PMC8497469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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