Article
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status.
The European respiratory journal - 1 May 2010
Martineau A R, Leandro A C C S, Anderson S T, Newton S M, Wilkinson K A, Nicol M P, Pienaar S M, Skolimowska K H, Rocha M A, Rolla V C, Levin M, Davidson R N, Bremner S A, Griffiths C J, Eley B S, Bonecini-Almeida M G, Wilkinson R J
Abstract excerpt
Group-specific component (Gc) variants of vitamin D binding protein differ in their affinity for vitamin D metabolites that modulate antimycobacterial immunity. We conducted studies to determine whether Gc genotype associates with susceptibility to tuberculosis (TB). The following subjects were recruited into case-control studies: in the UK, 123 adult TB patients and 140 controls, all of Gujarati Asian ethnic...
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