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Article

Functional gene polymorphisms in canadian aboriginal populations with high rates of tuberculosis.

The Journal of infectious diseases - 15 Oct 2008

Larcombe Linda A, Orr Pamela H, Lodge Andrew M, Brown Jodie S, Dembinski Iga J, Milligan Leisel C, Larcombe Erin A, Martin Bruce D, Nickerson Peter W

Abstract excerpt

The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dené and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-gamma (+874), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18713057
DOI: 10.1086/592049

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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