Article
Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.
Inhalation toxicology - 1 Feb 2015
Frampton Mark W, Pietropaoli Anthony, Dentler Michael, Chalupa David, Little Erika L, Stewart Judith, Frasier Lauren, Oakes David, Wiltshire Jelani, Vora Rathin, Utell Mark J
Abstract excerpt
CONTEXT: Exposure to ozone has acute respiratory effects, but few human clinical studies have evaluated cardiovascular effects. OBJECTIVE: We hypothesized that ozone exposure alters pulmonary and systemic vascular function, and cardiac function, with more pronounced effects in subjects with impaired antioxidant defense from deletion of the glutathione-S-transferase M1 gene (GSTM1 null). METHODS: Twenty-four...
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