Article
Movement of the retinylidene Schiff base counterion in rhodopsin by one helix turn reverses the pH dependence of the metarhodopsin I to metarhodopsin II transition.
The Journal of biological chemistry - 5 Mar 1993
Zvyaga T A, Min K C, Beck M, Sakmar T P
Abstract excerpt
The environment of the retinylidene Schiff base in bovine rhodopsin has been studied by movement of its carboxylic acid counterion from position 113 to position 117 by site-specific mutagenesis. Replacement of the counterion at position 113 by a neutral amino acid residue has been shown to produc...
Topics
- Amino Acid Sequence
- Animals
- Cattle
- Cells, Cultured
- Hydrogen-Ion Concentration
- Hydroxylamine
- Hydroxylamines
- Light
- Molecular Sequence Data
- Mutation
- Photochemistry
- Rhodopsin
- Schiff Bases
- Spectrophotometry, Ultraviolet
- Transducin