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Article

Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.

The Journal of biological chemistry - 31 Dec 2004

Janz Jay M, Farrens David L

Abstract excerpt

Little is known about the molecular mechanism of Schiff base hydrolysis in rhodopsin. We report here our investigation into this process focusing on the role of amino acids involved in a hydrogen bond network around the retinal Schiff base. We find conservative mutations in this network (T94I, E113Q, S186A, E181Q, Y192F, and Y268F) increase the activation energy (E(a)) and abolish the concave Arrhenius plot...

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PMID: 15475355
DOI: 10.1074/jbc.M408766200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.PMID 15475355Read ↗

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