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Article

Persistent ectopic expression of Drosophila homeotic genes resulting from maternal deficiency of the extra sex combs gene product.

Developmental biology - 1 Dec 1990

Glicksman M A, Brower D L

Abstract excerpt

Like other members of the Polycomb group, the extra sex combs gene (esc) is required for the correct repression of loci in the major homeotic gene complexes. We show here that embryos lacking both maternal and zygotic esc+ function display transient, general derepression of both the Ultrabithorax (Ubx) and Antennapedia (Antp) genes during germ band shortening, but Sex combs reduced (Scr) expression is almost...

Topics

Alleles
Animals
Drosophila
Drosophila Proteins
Female
Fluorescent Antibody Technique
Gene Expression
Genes, Homeobox
Insect Hormones
Larva
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Zygote

Source

Identifiers

PMID: 1979545
DOI: 10.1016/0012-1606(90)90364-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979545-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Persistent ectopic expression of Drosophila homeotic genes resulting from maternal deficiency of the extra sex combs gene product.PMID 1979545Read ↗

The Drosophila extra sex combs protein contains WD motifs essential for its function as a repressor of homeotic genes.Semantic proximity Read ↗

Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wg.Semantic proximity Read ↗

Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products.Semantic proximity Read ↗

The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development.Semantic proximity Read ↗

Genetic interactions and dosage effects of Polycomb group genes of Drosophila.Semantic proximity Read ↗

Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.Semantic proximity Read ↗

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.Semantic proximity Read ↗

The extra sex combs product contains WD40 repeats and its time of action implies a role distinct from other Polycomb group products.Semantic proximity Read ↗

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.Semantic proximity Read ↗

Effects of Polycomb group mutations on the expression of Ultrabithorax in the Drosophila visceral mesoderm.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

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