Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition.

Disease models & mechanisms - 1 Apr 2014

MacDonald Elizabeth M, Andres-Mateos Eva, Mejias Rebeca, Simmers Jessica L, Mi Ruifa, Park Jae-Sung, Ying Stephanie, Hoke Ahmet, Lee Se-Jin, Cohn Ronald D

Abstract excerpt

The purpose of our study was to compare two acquired muscle atrophies and the use of myostatin inhibition for their treatment. Myostatin naturally inhibits skeletal muscle growth by binding to ActRIIB, a receptor on the cell surface of myofibers. Because blocking myostatin in an adult wild-type mouse induces profound muscle hypertrophy, we applied a soluble ActRIIB receptor to models of disuse (limb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type II
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy

Share to Myostatin

Share to Proto-Oncogene Proteins c-akt

Share to Sirolimus

Share to TOR Serine-Threonine Kinases

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 24504412
DOI: 10.1242/dmm.014126
PMCID: PMC3974457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition.PMID 24504412Read ↗

Interference with Myostatin/ActRIIB Signaling as a Therapeutic Strategy for Duchenne Muscular DystrophySemantic proximity Read ↗

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin LigasesSemantic proximity Read ↗

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms.Semantic proximity Read ↗

Maintaining skeletal muscle mass: lessons learned from hibernation.Semantic proximity Read ↗

Myostatin: a modulator of skeletal-muscle stem cellsSemantic proximity Read ↗

Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3βSemantic proximity Read ↗

Smad2 and 3 transcription factors control muscle mass in adulthood.Semantic proximity Read ↗

Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteinsSemantic proximity Read ↗

Muscle regeneration through myostatin inhibitionSemantic proximity Read ↗

The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasis.Semantic proximity Read ↗

Balanced Diet-Fed Fat-1 Transgenic Mice Exhibit Lower Hindlimb Suspension-Induced Soleus Muscle Atrophy.Semantic proximity Read ↗

Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.