Article
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene.
Brain pathology (Zurich, Switzerland) - 1 Jul 2009
Sievert Angela J, Jackson Eric M, Gai Xiaowu, Hakonarson Hakon, Judkins Alexander R, Resnick Adam C, Sutton Leslie N, Storm Phillip B, Shaikh Tamim H, Biegel Jaclyn A
Abstract excerpt
In the present study, DNA from 28 pediatric low-grade astrocytomas was analyzed using Illumina HumanHap550K single-nucleotide polymorphism oligonucleotide arrays. A novel duplication in chromosome band 7q34 was identified in 17 of 22 juvenile pilocytic astrocytomas and three of six fibrillary astrocytomas. The 7q34 duplication spans 2.6 Mb of genomic sequence and contains approximately 20 genes, including two...
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