Multipoint linkage analysis and heterogeneity testing in 20 X-linked retinitis pigmentosa families.

doi:10.1016/0888-7543(90)90284-2

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Article

Multipoint linkage analysis and heterogeneity testing in 20 X-linked retinitis pigmentosa families.

Genomics - 1 Oct 1990

Musarella M A, Anson-Cartwright L, Leal S M, Gilbert L D, Worton R G, Fishman G A, Ott J

Abstract excerpt

Using multipoint linkage analysis in 20 families segregating for X-linked retinitis pigmentosa (XLRP), the lod scores on a map of eight RFLP loci were obtained. Our results indicate that under the hypothesis of homogeneity the maximal multipoint lod score supports one disease locus located slight...

Topics

Alleles
Chromosome Mapping
Female
Genetic Markers
Humans
Lod Score
Male
Pedigree
Polymorphism, Restriction Fragment Length
Retinitis Pigmentosa
X Chromosome

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