Article
Heterogeneity analysis in 40 X-linked retinitis pigmentosa families.
American journal of human genetics - 1 Jul 1994
Teague P W, Aldred M A, Jay M, Dempster M, Harrison C, Carothers A D, Hardwick L J, Evans H J, Strain L, Brock D J
Abstract excerpt
Analysis of genetic heterogeneity in 40 kindreds with X-linked retinitis pigmentosa (XLRP), with 20 polymorphic markers, showed that significant heterogeneity is present (P = .001) and that 56% of kindreds are of RP3 type and that 26% are of RP2 type. The location of the RP3 locus was found to be...
Topics
- Bayes Theorem
- Chi-Square Distribution
- Female
- Genetic Linkage
- Genotype
- Heterozygote
- Humans
- Lod Score
- Male
- Odds Ratio
- Phenotype
- Polymorphism, Genetic
- Retinitis Pigmentosa
- Sex Chromosome Aberrations
- X Chromosome