Localization of the X-linked ocular albinism gene (OA1) between DXS278/DXS237 and DXS143/DXS16 by linkage analysis.

doi:10.3109/13816819009020975

Back to search

Article

Localization of the X-linked ocular albinism gene (OA1) between DXS278/DXS237 and DXS143/DXS16 by linkage analysis.

Ophthalmic paediatrics and genetics - 1 Sept 1990

Bergen A A, Samanns C, Van Dorp D B, Ferguson-Smith M A, Gal A, Bleeker-Wagemakers E M

Abstract excerpt

Linkage analysis was performed in six families segregating for X-linked ocular albinism of the Nettleship-Falls type using four polymorphic DNA markers from the distal Xp. Linkage was found between the disease locus (OA1) and the loci DXS237 (theta max = 0.06, Zmax = 2.82), DXS278 (theta max = 0....

Topics

Albinism, Ocular
Blotting, Southern
DNA Probes
Female
Genetic Linkage
Genetic Markers
Genotype
Humans
Male
Pedigree
X Chromosome

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.