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Article

DNA linkage studies in the fragile X syndrome suggest genetic heterogeneity.

American journal of medical genetics - 1 Jan 2000

Brown W T, Gross A C, Chan C B, Jenkins E C

Abstract excerpt

Previously, we showed genetic heterogeneity for linkage between the fra(X) locus and a factor IX DNA RFLP (Brown et al, 1985). When fra(X) families were predivided into two classes, one containing those with non-penetrant (NP) males and one with apparent full penetrance (P), evidence of significant heterogeneity was present. We have now extended this analysis by adding DNA linkage information on 2 additional...

Topics

DNA
DNA Restriction Enzymes
Factor IX
Female
Fragile X Syndrome
Genetic Linkage
Genetic Markers
Humans
Lod Score
Male
Pedigree
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Recombination, Genetic

Sex Chromosome Aberrations

Source

Identifiers

PMID: 3006490
DOI: 10.1002/ajmg.1320230158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3006490-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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