Article
Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome.
Arthritis and rheumatism - 1 Oct 2009
Kabalak G, Dobberstein S B, Matthias T, Reuter S, The Y-H, Dörner T, Schmidt R E, Witte T
Abstract excerpt
OBJECTIVE: The immunoglobulin-like transcript (ILT) family is located in chromosomal region 19q13 and consists of a group of activating and inhibitory receptors. The ILT receptors are expressed on antigen-presenting cells (macrophages, dendritic cells, B lymphocytes), as well as on T cells and natural killer cells. ILT2 and ILT4 play a role in tolerance induction, and ILT3 has been shown to induce Treg cells. A...
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