Article
Polymorphism and linkage disequilibrium of immunoglobulin-like transcript 3 gene.
Human immunology - 1 Jan 2000
Chang Chih-Chao, Silvia Elaine A, Ho Eric K, Vlad George, Suciu-Foca Nicole, Vasilescu E Rodica
Abstract excerpt
Immunoglobulin-like transcript 3 (ILT3) is an inhibitory receptor molecule expressed by dendritic cells, monocytes, and endothelial cells. Upon upregulation of ILT3 expression, antigen presenting cells (APCs) become tolerogenic, triggering the differentiation of antigen-specific CD8(+) and CD4(+) regulatory T cells. To analyze the polymorphism of ILT3, we screened DNA from a panel of 150 healthy subjects for...
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