Article
Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis.
Critical care medicine - 1 May 2004
Texereau Joelle, Pene Frédéric, Chiche Jean-Daniel, Rousseau Christophe, Mira Jean-Paul
Abstract excerpt
Individuals vary considerably in their susceptibility to infection and in their ability to recover from apparently similar infectious processes. These differences can be partially explained by polymorphisms of the genes encoding proteins involved in mediating and controlling the innate immune response, the inflammatory cascade, coagulation, and fibrinolysis. It is evident from experimental studies that...
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