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Article

Protective role of cisplatin in ischemic liver injury through induction of autophagy

16 Nov 2009

Abstract excerpt

High mobility group box 1 (HMGB1) is a nuclear protein released from stressed or damaged cells that activates inflammatory cascades involved in the pathogenesis of liver ischemia reperfusion (I/R) injury. In efforts to develop strategies aimed at preventing its release from ischemic cells following I/R, we studied the use of cisplatin, a member of the platinating chemotherapeutic agents capable of inducing DNA...

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PMID: 19786828
DOI: 10.4161/auto.5.8.9972

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