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Article

Detecting natural selection by empirical comparison to random regions of the genome.

Human molecular genetics - 15 Dec 2009

Yu Fuli, Keinan Alon, Chen Hua, Ferland Russell J, Hill Robert S, Mignault Andre A, Walsh Christopher A, Reich David

Abstract excerpt

Historical episodes of natural selection can skew the frequencies of genetic variants, leaving a signature that can persist for many tens or even hundreds of thousands of years. However, formal tests for selection based on allele frequency skew require strong assumptions about demographic history...

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Identifiers

PMID: 19783549
DOI: 10.1093/hmg/ddp457
PMCID: PMC2778377

Genes

AHI1
FOXP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19783549-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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