Article
Cohesin mediates chromatin interactions that regulate mammalian β-globin expression.
The Journal of biological chemistry - 20 May 2011
Chien Richard, Zeng Weihua, Kawauchi Shimako, Bender M A, Santos Rosaysela, Gregson Heather C, Schmiesing John A, Newkirk Daniel A, Kong Xiangduo, Ball Alexander R, Calof Anne L, Lander Arthur D, Groudine Mark T, Yokomori Kyoko
Abstract excerpt
The β-globin locus undergoes dynamic chromatin interaction changes in differentiating erythroid cells that are thought to be important for proper globin gene expression. However, the underlying mechanisms are unclear. The CCCTC-binding factor, CTCF, binds to the insulator elements at the 5' and 3' boundaries of the locus, but these sites were shown to be dispensable for globin gene activation. We found that, upon...
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