Susceptibility to thyroid autoimmune disease: molecular analysis of HLA-D region genes identifies new markers for goitrous Hashimoto's thyroiditis.

doi:10.1210/jcem-71-5-1131

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Article

Susceptibility to thyroid autoimmune disease: molecular analysis of HLA-D region genes identifies new markers for goitrous Hashimoto's thyroiditis.

The Journal of clinical endocrinology and metabolism - 1 Nov 1990

Badenhoop K, Schwarz G, Walfish P G, Drummond V, Usadel K H, Bottazzo G F

Abstract excerpt

Hashimoto's thyroiditis has been shown to be associated with the HLA-specificities DR4 and DR5. Since former association studies yielded variable results, we used novel molecular typing methods to assess predisposing immunogenetic factors. Gene analysis of the HLA-DR-DQ and tumor necrosis factor...

Topics

Amino Acid Sequence
Genes
Genetic Markers
Genetic Predisposition to Disease
Goiter
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
Humans
Immunogenetics
Molecular Sequence Data
Pedigree
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1977755
DOI: 10.1210/jcem-71-5-1131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1977755-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Promoter Regions, Genetic

Thyroiditis, Autoimmune

Tumor Necrosis Factor-alpha