Article
Susceptibility to thyroid autoimmune disease: molecular analysis of HLA-D region genes identifies new markers for goitrous Hashimoto's thyroiditis.
The Journal of clinical endocrinology and metabolism - 1 Nov 1990
Badenhoop K, Schwarz G, Walfish P G, Drummond V, Usadel K H, Bottazzo G F
Abstract excerpt
Hashimoto's thyroiditis has been shown to be associated with the HLA-specificities DR4 and DR5. Since former association studies yielded variable results, we used novel molecular typing methods to assess predisposing immunogenetic factors. Gene analysis of the HLA-DR-DQ and tumor necrosis factor region was performed in a group of Hashimoto's thyroiditis patients and randomly chosen controls using standards and...
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