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Article

In vivo monitoring of a cAMP-stimulated DNA-binding activity.

Genes & development - 1 Aug 1990

Weih F, Stewart A F, Boshart M, Nitsch D, Schütz G

Abstract excerpt

The transcriptional activity of the tyrosine aminotransferase (TAT) gene is influenced by two major signal transduction pathways, by glucocorticoids and by glucagon acting via cAMP. We analyzed the effect of cAMP on protein-DNA interactions in vivo and on the transcription rate of the TAT gene. We demonstrate that a cAMP-responsive element (CRE) is located in a tissue-specific DNase I-hypersensitive region, 3.6...

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Identifiers

PMID: 1977662
DOI: 10.1101/gad.4.8.1437

Genes

TAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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