In vivo monitoring of a cAMP-stimulated DNA-binding activity.

doi:10.1101/gad.4.8.1437

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Article

In vivo monitoring of a cAMP-stimulated DNA-binding activity.

Genes & development - 1 Aug 1990

Weih F, Stewart A F, Boshart M, Nitsch D, Schütz G

Abstract excerpt

The transcriptional activity of the tyrosine aminotransferase (TAT) gene is influenced by two major signal transduction pathways, by glucocorticoids and by glucagon acting via cAMP. We analyzed the effect of cAMP on protein-DNA interactions in vivo and on the transcription rate of the TAT gene. W...

Topics

Base Sequence
Cell Line
Cloning, Molecular
Cyclic AMP
Cyclic AMP Response Element-Binding Protein
Cycloheximide
DNA
DNA-Binding Proteins
Deoxyribonuclease I
Gene Expression Regulation, Enzymologic
Molecular Sequence Data
Mutation
Regulatory Sequences, Nucleic Acid
Signal Transduction
Transcription, Genetic
Tyrosine Transaminase

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PMID: 1977662
DOI: 10.1101/gad.4.8.1437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1977662-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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