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Article

Packaging of Host mY RNAs by Murine Leukemia Virus May Occur Early in Y RNA Biogenesis

24 Sept 2009

Abstract excerpt

Moloney murine leukemia virus (MLV) selectively encapsidates host mY1 and mY3 RNAs. These noncoding RNA polymerase III transcripts are normally complexed with the Ro60 and La proteins, which are autoantigens associated with rheumatic disease that function in RNA biogenesis and quality control. Here, MLV replication and mY RNA packaging were analyzed using Ro60 knockout embryonic fibroblasts, which contain only...

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PMID: 19776129
DOI: 10.1128/jvi.01219-09

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